| Identification | Back Directory | [Name]
1H-Purine-2,6-dione, 8-[[(3-bromophenyl)methyl]amino]-1,3-diethyl-3,7-dihydro-7-methyl- | [CAS]
2550401-76-6 | [Synonyms]
Adenosine receptor inhibitor 2
1H-Purine-2,6-dione, 8-[[(3-bromophenyl)methyl]amino]-1,3-diethyl-3,7-dihydro-7-methyl- | [Molecular Formula]
C17H20BrN5O2 | [MOL File]
2550401-76-6.mol | [Molecular Weight]
406.28 |
| Hazard Information | Back Directory | [Uses]
Adenosine receptor inhibitor 2 (compound 14b) is a potent AR (adenosine receptor) inhibitor. Adenosine receptor inhibitor 2 shows dual affinity toward A1/A2A ARs with higher affinity for the A1- than the A2AAR. Adenosine receptor inhibitor 2 has Ki values of 52.2 nM for the A1AR and 167 nM for the A2AAR[1]. | [IC 50]
A1AR: 52.2 ± 8.5 nM (Ki); A2AR: 167 ± 22 nM (Ki); hA2B: >1000 nM (Ki); Adenosine A3 receptor: >1000 nM (Ki) | [References]
[1] Za?uski M, et al. 8-Benzylaminoxanthine scaffold variations for selective ligands acting on adenosine A2A receptors. Design, synthesis and biological evaluation. Bioorg Chem. 2020 Aug;101:104033. DOI:10.1016/j.bioorg.2020.104033 |
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