| Identification | Back Directory | [Name]
bruceine A | [CAS]
25514-31-2 | [Synonyms]
NSC31616
bruceine A
NSC 310616
Dihydrobrusatol
Brucea javanica A
Bruceine A 25514-31-2
Bruceine A (Dihydrobrusatol
13,20-Epoxy-3,11β,12α-trihydroxy-15β-(3-methyl-1-oxobutoxy)-2,16-dioxopicras-3-en-21-oic acid methyl ester
Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-(3-methyl-1-oxobutoxy)-2,16-dioxo-, methyl ester, (11β,12α,15β)- | [Molecular Formula]
C26H34O11 | [MDL Number]
MFCD28167765 | [MOL File]
25514-31-2.mol | [Molecular Weight]
522.54 |
| Chemical Properties | Back Directory | [Boiling point ]
712.6±60.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
insoluble in EtOH; insoluble in H2O; ≥5.23 mg/mL in DMSO with gentle warming | [form ]
Powder | [pka]
8.81±0.70(Predicted) |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the fruit of bruce chinensis. | [Uses]
Bruceantin A acts as an anti-babesial quassinoid, extracted from the fruits of Brucea javanica, also an effective anti-trypanosomal agent in vitro. Cytotoxic agent. | [Definition]
ChEBI: Bruceine A is a quassinoid. | [Biological Activity]
ic50: 7.7 nm against the parasitescanine babesiosis is a tick-borne disease caused by the intraerythrocytic apicomplexan parasites, babesia gibsoni and b. canis. clinical signs of b. gibsoni infection are anemia, fever, thrombocytopenia, splenomegaly, lymphadenopathy, and lethargy. bruceine a, a natural quassinoid compound extracted from the brucea javanica (l.) merr. dried fruits, was reported to have antibabesial activity. | [Physiological effects]
Bruisein A has an effect of treating malignant tumor, antimalarial and anti-inflammatory. | [in vitro]
bruceine a inhibited the in-vitro babesia gibsoni growth in canine erythrocytes at lower concentration compared with the antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nm [1]. | [in vivo]
oral administration of bruceine a at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog. an untreated dog developed typical acute babesiosis symptoms including high fever, severe anemia, and complete loss of appetite and movement. however, the two bruceine a-treated dogs maintained their healthy conditions throughout the experimental period of 4 weeks [1]. | [target]
Antifection | p65 | NF-kB | ROS | [References]
[1] nakao r, mizukami c, kawamura y, subeki, bawm s, yamasaki m, maede y, matsuura h, nabeta k, nonaka n, oku y, katakura k. evaluation of efficacy of bruceine a, a natural quassinoid compound extracted from a medicinal plant, brucea javanica, for canine babesiosis. j vet med sci. 2009 jan;71(1):33-41. |
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