| Identification | Back Directory | [Name]
2',4,4',6'-TETRAHYDROXYCHALCONE | [CAS]
25515-46-2 | [Synonyms]
Naringenin chalcon
cNaringenin chalcone
2',4,4',6'-TETRAHYDROXYCHALCONE
1-(2,4,6-Trihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propene-1-one
2-Propen-1-one, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-, (2E)- | [Molecular Formula]
C15H12O5 | [MDL Number]
MFCD00016762 | [MOL File]
25515-46-2.mol | [Molecular Weight]
272.25 |
| Chemical Properties | Back Directory | [Boiling point ]
538.7±50.0 °C(Predicted) | [density ]
1.483±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
6.94±0.40(Predicted) | [Major Application]
food and beverages | [InChI]
1S/C15H12O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-8,16-17,19-20H/b6-3+ | [InChIKey]
YQHMWTPYORBCMF-ZZXKWVIFSA-N | [SMILES]
Oc1c(c(cc(c1)O)O)C(=O)\C=C\c2ccc(cc2)O |
| Hazard Information | Back Directory | [Uses]
food and beverages | [Definition]
ChEBI: 2',4,4',6'-tetrahydroxychalcone is a member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 2' ,4, 4', and 6' respectively. It has a role as a metabolite, an anti-allergic agent and an anti-inflammatory agent. It is a polyphenol and a member of chalcones. It is functionally related to a trans-chalcone. | [in vivo]
(E)-Naringenin chalcone (0.8 mg/kg, oral administration) shows anti-allergic effect in type I allergic mice[1].
(E)-Naringenin chalcone (0.8 mg/kg, oral administration) suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells in allergic airway inflammatory mice[3].
| Animal Model: | Mouse type I allergic model[1] | | Dosage: | 0.8 mg/kg | | Administration: | Oral administration | | Result: | Inhibited the ear-swelling response, with the inhibitory ratio of 46.7%. |
| Animal Model: | Allergic airway inflammation induced in mice[3] | | Dosage: | 0.8 mg/kg | | Administration: | Oral administration, daily | | Result: | Decreased cell numbers of the infiltrating leukocyte and eosinophils.
Decreased Muc5ac and gob-5 expression in the lungs.
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