| Identification | Back Directory | [Name]
2',4,4',6'-TETRAHYDROXYCHALCONE | [CAS]
25515-46-2 | [Synonyms]
Naringenin chalcon
cNaringenin chalcone
2',4,4',6'-TETRAHYDROXYCHALCONE
1-(2,4,6-Trihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propene-1-one
2-Propen-1-one, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-, (2E)- | [Molecular Formula]
C15H12O5 | [MDL Number]
MFCD00016762 | [MOL File]
25515-46-2.mol | [Molecular Weight]
272.25 |
| Hazard Information | Back Directory | [Uses]
food and beverages | [Definition]
ChEBI: 2',4,4',6'-tetrahydroxychalcone is a member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 2' ,4, 4', and 6' respectively. It has a role as a metabolite, an anti-allergic agent and an anti-inflammatory agent. It is a polyphenol and a member of chalcones. It is functionally related to a trans-chalcone. | [in vivo]
(E)-Naringenin chalcone (0.8 mg/kg, oral administration) shows anti-allergic effect in type I allergic mice[1].
(E)-Naringenin chalcone (0.8 mg/kg, oral administration) suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells in allergic airway inflammatory mice[3].
| Animal Model: | Mouse type I allergic model[1] | | Dosage: | 0.8 mg/kg | | Administration: | Oral administration | | Result: | Inhibited the ear-swelling response, with the inhibitory ratio of 46.7%. |
| Animal Model: | Allergic airway inflammation induced in mice[3] | | Dosage: | 0.8 mg/kg | | Administration: | Oral administration, daily | | Result: | Decreased cell numbers of the infiltrating leukocyte and eosinophils.
Decreased Muc5ac and gob-5 expression in the lungs.
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