| Identification | Back Directory | [Name]
Acetamide, 2-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-6,7-dimethoxy-2-quinazolinyl]sulfinyl]-N-(4-cyanophenyl)- | [CAS]
2554622-28-3 | [Synonyms]
HIV-1 inhibitor-23
Acetamide, 2-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-6,7-dimethoxy-2-quinazolinyl]sulfinyl]-N-(4-cyanophenyl)- | [Molecular Formula]
C30H26N6O4S | [MOL File]
2554622-28-3.mol | [Molecular Weight]
566.63 |
| Hazard Information | Back Directory | [Uses]
HIV-1 inhibitor-23 (compound 12a) is a highly potent HIV-1 non-nucleoside reverse transcriptase inhibitor, with EC50s of 24.9 nM and 10.4 nM for HIV-1 WT and HIV-1 K103N, respectively. HIV-1 inhibitor-23 has low cytotoxicity (CC50?>?221?μM) and a favorable in vitro microsomal stability[1]. | [IC 50]
HIV-1 (WT): 24.9 nM (EC50); HIV-1 (K103N): 10.4 nM (EC50) | [References]
[1] Han S, et al. Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors. Eur J Med Chem. 2020;185:111874. DOI:10.1016/j.ejmech.2019.111874 |
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