| Identification | Back Directory | [Name]
2H-Pyran-4-carbonitrile, 4-[[[4-[5-chloro-2-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino]-4-pyridinyl]-2-thiazolyl]amino]methyl]tetrahydro-, (2Z)-2-butenedioate (1:2) | [CAS]
2559759-04-3 | [Synonyms]
| [Molecular Formula]
C25H35ClN6O2S.2C4H4O4 | [MOL File]
2559759-04-3.mol | [Molecular Weight]
751.25 |
| Hazard Information | Back Directory | [Uses]
JSH-009 dimaleate (Compound 1) is a potent and highly selective CDK9 inhibitor with an IC50 of 0.928 nM. JSH-009 can effectively inhibit the growth of subcutaneous tumor (cute myelogenous leukemia MV4-11) mice[1]. | [IC 50]
CDK9/cyclinT1: 0.928 nM (IC50); CDK1/cyclinB: 5410 nM (IC50); CDK2/cyclinA: 6850 nM (IC50); CDK3/cyclin E1: >10,000 nM (IC50); Cdk5/p25: 6950 nM (IC50); CDK7/Cyclin H/MNAT1: 3700 nM (IC50); CDK8/cyclin C: >10,000 nM (IC50); CDK11: >10,000 nM (IC50); CDK14/Cyclin Y: 2710 nM (IC50); CDK16/Cyclin Y: 195 nM (IC50) | [References]
[1] Gang Zhou. A kind of novel cell cyclin-dependent kinase CDK9 inhibitor. CN108727363A. |
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