| Identification | Back Directory | [Name]
1-Pyrrolidinepropanoic acid, 2-[[[7-(8-chloro-1-naphthalenyl)-4-[(3S)-3-(cyanomethyl)-4-(2-fluoro-1-oxo-2-propen-1-yl)-1-piperazinyl]-5,6,7,8- | [CAS]
2561529-96-0 | [Synonyms]
MRTX849 acid
1-Pyrrolidinepropanoic acid, 2-[[[7-(8-chloro-1-naphthalenyl)-4-[(3S)-3-(cyanomethyl)-4-(2-fluoro-1-oxo-2-propen-1-yl)-1-piperazinyl]-5,6,7,8- | [Molecular Formula]
C34H37ClFN7O4 | [MDL Number]
MFCD34567051 | [MOL File]
2561529-96-0.mol | [Molecular Weight]
662.15 |
| Chemical Properties | Back Directory | [Boiling point ]
948.6±75.0 °C(Predicted) | [density ]
1.337±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.83±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
MRTX849 acid, a derivative of MRTX849, can be used in the synthesis of PROTAC LC-2 (HY-137516). LC-2 is a potent and first-in-class PROTAC capable of degrading endogenous KRAS G12C (DC50s between 0.25 and 0.76 μM)[1][2]. | [IC 50]
KRas G12C | [References]
[1] Bond MJ, et al. Targeted Degradation of Oncogenic KRASG12C by VHL-Recruiting PROTACs. ACS Cent Sci. 2020;6(8):1367-1375. DOI:10.1021/acscentsci.0c00411 |
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