| Identification | Back Directory | [Name]
2,6-Piperidinedione, 3-[5-[cis-4-[4-[4-[3-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-3,8-diazabicyclo[3.2.1]oct-8-yl]-2-pyrimidinyl]-1-piperidinyl]cyclohexyl]-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl]- | [CAS]
2568273-82-3 | [Synonyms]
2,6-Piperidinedione, 3-[5-[cis-4-[4-[4-[3-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-3,8-diazabicyclo[3.2.1]oct-8-yl]-2-pyrimidinyl]-1-piperidinyl]cyclohexyl]-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl]- | [Molecular Formula]
C44H51N11O4 | [MOL File]
2568273-82-3.mol | [Molecular Weight]
797.95 |
| Hazard Information | Back Directory | [Uses]
PROTAC SMARCA2/4-degrader-29 (Compound I-279) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-29 degrades SMARCA2 in A549 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 <100 nM. (Pink: ligand for target protein (HY-163926); Black: linker (HY-159682); Blue: ligand for E3 ligase (HY-W382038))[1]. | [References]
[1] Ji N, et al., Smarca degraders and uses thereof. US20230072658A1. |
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