2568277-50-7

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2568277-50-7 Structure

Identification	Back Directory
[Name] PROTAC SMARCA2/4-degrader-23
[CAS] 2568277-50-7
[Synonyms] PROTAC SMARCA2/4-degrader-23
[Molecular Formula] C52H64N12O6S
[MOL File] 2568277-50-7.mol
[Molecular Weight] 985.21

Chemical Properties	Back Directory
[density ] 1.398±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[pka] 6.274±0.30(predicted)

Hazard Information	Back Directory
[Uses] SMARCA2 degrader-15 (compound I-409) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC50s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment[1].
[References] [1] Preparation of heterocyclic compounds as SMARCA degraders and uses thereof. World Intellectual Property Organization, WO2020251971 A1 2020-12-17.

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