| Identification | Back Directory | [Name]
L-THREO-SPHINGOSINE | [CAS]
25695-95-8 | [Synonyms]
L-THREO-SPHINGOSINE
L-threo-C18-Sphingosine
L-THREO-SPHINGOSINE C-18
threo-(2S,3S)-Sphingosine
L-threo-sphingosine (d18:1)
L-THREO-SPHINGOSINE, C18 CHAIN
(2S,3S,E)-2-Aminooctadec-4-ene-1,3-diol
(2S,3S,4E)-2-Amino-4-octadecene-1,3-diol
(2S,3S,4E)-2-AMINO-1,3-OCTADEC-4-ENEDIOL
(2S,3S,4E)-2-AMINOOCTADEC-4-ENE-1,3-DIOL
4-Octadecene-1,3-diol, 2-amino-, (2S,3S,4E)-
L threo Sphingosine C 18,LthreoSphingosine C18
(2S,3S,4E)-2-AMINOOCTADEC-4-ENE-1,3-DIOL;L-THREO-SPHINGOSINE (D18:1) | [Molecular Formula]
C18H37NO2 | [MDL Number]
MFCD02259136 | [MOL File]
25695-95-8.mol | [Molecular Weight]
299.49 |
| Chemical Properties | Back Directory | [Melting point ]
86-88 °C | [Boiling point ]
445.9±45.0 °C(Predicted) | [density ]
0.939±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Ethanol: 0.25 mg/ml | [form ]
A crystalline solid | [pka]
11.80±0.45(Predicted) | [InChI]
1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18-/m0/s1 | [InChIKey]
WWUZIQQURGPMPG-DNWQSSKHSA-N | [SMILES]
CCCCCCCCCCCCC/C=C/[C@@](O)([H])[C@@]([H])(N)CO |
| Hazard Information | Back Directory | [Uses]
L-threo-Sphingosine is a potent MAPK inhibitor. L-threo-Sphingosine induces apoptosis and clear DNA fragmentation. L-threo-Sphingosine shows anticancer effect[1]. | [Definition]
ChEBI: L-threo-Sphingosine is an amino alcohol. | [References]
[1] Sakakura C, et al. Selectivity of sphingosine-induced apoptosis. Lack of activity of DL-erythyro-dihydrosphingosine. Biochem Biophys Res Commun. 1998 May 29;246(3):827-30. DOI:10.1006/bbrc.1998.8719 |
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