| Identification | Back Directory | [Name]
BIO-7488 | [CAS]
2573211-25-1 | [Synonyms]
BIO-7488 Imidazo[1,2-a]pyrimidine-6-carboxamide, 7-(1-methylethoxy)-2-(1-methyl-2-oxabicyclo[2.1.1]hex-4-yl)-N-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)- | [Molecular Formula]
C23H25N7O3 | [MOL File]
2573211-25-1.mol | [Molecular Weight]
447.49 |
| Chemical Properties | Back Directory | [density ]
1.52±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
7.44±0.46(predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
BIO-7488 is a potent, selective, oral active and CNS-penetrant IRAK4 inhibitor with the IC50 of 0.6 nM and > 30 μM for IRAK4 and hERG, respectively[1]. | [IC 50]
hIRAK4: 0.6 nM (IC50) | [References]
[1] Ryan Evans, et al. The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-N-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)imidazo[1,2-a]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke. J.Med. Chem. 2024. |
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