| Identification | Back Directory | [Name]
Imidazo[1,5-b]pyridazine, 2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)- | [CAS]
2574545-45-0 | [Synonyms]
ATR-IN-4
Imidazo[1,5-b]pyridazine, 2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)- | [Molecular Formula]
C18H20N8O | [MOL File]
2574545-45-0.mol | [Molecular Weight]
364.4 |
| Hazard Information | Back Directory | [Uses]
ATR-IN-4 is a potent ATR (Ataxia telangiectasia mutated gene Rad 3-associated kinase) inhibitor. ATR-IN-4 inhibits growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460 with IC50s of 130.9 nM and 41 .33 nM, respectively. (Patent CN112142744A, compound 13)[1]. | [References]
[1] Substituted fused heteroaromatic bicyclic compounds as kinase inhibitors and uses thereof. CN112142744A. |
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