| Identification | Back Directory | [Name]
1,4-Cyclohexadiene-1-propanamide, N-[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]-4,5-dimethoxy-β,β,2-trimethyl-3,6-dioxo-, hydrochloride (1:3) | [CAS]
2576358-68-2 | [Synonyms]
Spermine Prodrug-1
1,4-Cyclohexadiene-1-propanamide, N-[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]-4,5-dimethoxy-β,β,2-trimethyl-3,6-dioxo-, hydrochloride (1:3) | [Molecular Formula]
C24H43ClN4O5 | [MOL File]
2576358-68-2.mol | [Molecular Weight]
503.08 |
| Hazard Information | Back Directory | [Uses]
Spermine precursor-1 (Compound 1) is a redox-sensitive spermine precursor for the potential research of snyder robinson syndrome. Spermine precursor-1 inhibits wild-type (CMS-24949) and spermine synthase gene (SMS) mutant (CMS-26559, and CMS-6233) fibroblast cells with IC50s of 326.7, 198.5, and 244.1 μM, respectively[1]. | [References]
[1] Mukund P Tantak, et al. Development of a Redox-Sensitive Spermine Prodrug for the Potential Treatment of Snyder Robinson Syndrome. J Med Chem. 2021 Nov 11;64(21):15593-15607. DOI:10.1021/acs.jmedchem.1c00419
[2] Mukund P Tantak, et al. Development of a Redox-Sensitive Spermine Prodrug for the Potential Treatment of Snyder Robinson Syndrome. J Med Chem. 2021 Nov 11;64(21):15593-15607. |
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