| Identification | Back Directory | [Name]
N-DESMETHYL ROSIGLITAZONE | [CAS]
257892-31-2 | [Synonyms]
SB 237216
N-DESMETHYL ROSIGLITAZONE
N-Desmethyl Rosiglitazone Solution, 100ppm
5-[[4-[2-(2-pyridinylamino]ethoxy]phenyl]methyl]-2,4-thiazolidinedione
2,4-Thiazolidinedione, 5-[[4-[2-(2-pyridinylamino)ethoxy]phenyl]methyl]-
N-Desmethyl RosiglitazoneQ: What is
N-Desmethyl Rosiglitazone Q: What is the CAS Number of
N-Desmethyl Rosiglitazone Q: What is the storage condition of
N-Desmethyl Rosiglitazone Q: What are the applications of
N-Desmethyl Rosiglitazone | [Molecular Formula]
C17H17N3O3S | [MDL Number]
MFCD08063704 | [MOL File]
257892-31-2.mol | [Molecular Weight]
343.4 |
| Chemical Properties | Back Directory | [Melting point ]
177-179°C | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Off-White to Pale Beige |
| Hazard Information | Back Directory | [Description]
N-desmethyl Rosiglitazone is a major metabolite of rosiglitazone (Item Nos. 71740 | 71742 | 11884), a potent and selective PPARγ ligand present in formulations that have been used to treat type 2 diabetes. Rosiglitazone is metabolized by the cytochrome P450 (CYP) isoform CYP2C8 to form N-desmethyl rosiglitazone. | [Chemical Properties]
White Solid | [Uses]
A metabolite of Rosiglitazone | [Uses]
A metabolite of Rosiglitazone. | [Definition]
ChEBI: N-desmethylrosiglitazone is an aromatic ether. | [References]
[1] J M LEHMANN. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma).[J]. The Journal of Biological Chemistry, 1995, 270 22: 12953-12956. DOI: 10.1074/jbc.270.22.12953
[2] KWON-BOK KIM . Simultaneous quantification of rosiglitazone and its two major metabolites, N-desmethyl and p-hydroxy rosiglitazone in human plasma by liquid chromatography/tandem mass spectrometry: Application to a pharmacokinetic study[J]. Journal of Chromatography B, 2009, 877 20: Pages 1951-1956. DOI: 10.1016/j.jchromb.2009.05.001 |
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BOC Sciences
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www.bocsci.com |
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Energy Chemical
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