| Identification | Back Directory | [Name]
2,4-Pentadienoic acid, 5-(1,3-benzodioxol-5-yl)-2-cyano-, phenylmethyl ester, (2E,4E)- | [CAS]
2581113-51-9 | [Synonyms]
hMAO-B-IN-3
2,4-Pentadienoic acid, 5-(1,3-benzodioxol-5-yl)-2-cyano-, phenylmethyl ester, (2E,4E)- | [Molecular Formula]
C20H15NO4 | [MOL File]
2581113-51-9.mol | [Molecular Weight]
333.34 |
| Hazard Information | Back Directory | [Uses]
hMAO-B-IN-3 (Compound 15) is a potent inhibitor of hMAO-B with an IC50 of 47.4 nM. hMAO-B-IN-3 is playing favourable agent-like properties and a broad safety window. hMAO-B-IN-3 is thus a suitable candidate for lead optimization and the development of multitarget-directed ligands[1]. | [References]
[1] Chavarria D, et al. Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies. Eur J Med Chem. 2020 Jan 1;185:111770. DOI:10.1016/j.ejmech.2019.111770 |
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