| Identification | Back Directory | [Name]
Benzeneacetamide, α-[(2-iodobenzoyl)phenylamino]-N-(4-nitrophenyl)- | [CAS]
2581824-80-6 | [Synonyms]
MMP-9-IN-5
Benzeneacetamide, α-[(2-iodobenzoyl)phenylamino]-N-(4-nitrophenyl)- | [Molecular Formula]
C27H20IN3O4 | [MOL File]
2581824-80-6.mol | [Molecular Weight]
577.38 |
| Hazard Information | Back Directory | [Uses]
MMP-9-IN-5 is a MMP-9 inhibitor (IC50: 4.49 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-5 also inhibits AKT activity (IC50: 1.34 nM). MMP-9-IN-5 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-5 can be used in the research of cancers[1]. | [IC 50]
MMP-9: 4.49 nM (IC50); MMP-1: 104 nM (IC50); MMP-2: 266 nM (IC50); MMP-13: 280 nM (IC50); AKT: 1.34 nM (IC50) | [References]
[1] Mohammed Salah Ayoup, et al. Battle tactics against MMP-9; discovery of novel non-hydroxamate MMP-9 inhibitors endowed with PI3K/AKT signaling attenuation and caspase 3/7 activation via Ugi bis-amide synthesis. Eur J Med Chem. 2020 Jan 15;186:111875. DOI:10.1016/j.ejmech.2019.111875 |
|
|