| Chemical Properties | Back Directory | [Boiling point ]
649.9±50.0 °C(Predicted) | [density ]
1.027±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
An oil | [pka]
14.26±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
PF-1163B is an antifungal agent produced by Penicillium sp. II. PF-1163B inhibits ergosterol (ERG) synthesis (IC50 = 34 ng/ml). PF-1163B showed potent growth inhibitory activity against pathogenic fungal strain Candida albicans but did not show cytotoxic activity against mammalian cells. | [Uses]
PF-1163B is an antifungal antibiotic[1]. | [Definition]
ChEBI: PF 1163B is a macrolide antibiotic that is 4,10-dimethyl-1-oxa-4-azacyclotridecane-2,5-dione substituted by a 4-(2-hydroxyethoxy)benzyl group at position 3 and a pentyl group at position 13 (the 3S,10R,13S stereoisomer). It is isolated from Penicillium sp.PF1163 and exhibits antifungal activity against the pathogenic fungal strain Candida albicans TIMM1768. It has a role as an antifungal agent and a Penicillium metabolite. It is a macrolide antibiotic, a lactam and an aromatic ether. | [References]
[1] Sasaki T, et al. PF1163A and B, new antifungal antibiotics produced by Penicillium sp. II. Physico-chemical properties and structure elucidation. J Antibiot (Tokyo). 2000 Jan;53(1):38-44. DOI:10.7164/antibiotics.53.38 |
|
|