| Identification | Back Directory | [Name]
CP 31398 | [CAS]
259199-65-0 | [Synonyms]
CP 31398
CP 31398 2HCl
CP 31398 dihydrochloride
p53 Modulator, CP-31398 - CAS 259199-65-0 - Calbiochem
1,3-Propanediamine, N3-[2-[2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]-N1,N1-dimethyl-
N'-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediaminedihydrochloride | [Molecular Formula]
C22H26N4O | [MDL Number]
MFCD11519956 | [MOL File]
259199-65-0.mol | [Molecular Weight]
362.47 |
| Hazard Information | Back Directory | [Uses]
CP-31398 is reported to restore p53 activity in mutant cells. | [Biological Activity]
p53 stabilizing agent. Stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Inhibits growth of small human tumor xenografts in vivo . | [in vivo]
CP-31398 (100 mg/kg, orally, twice daily for 7 days) exhibits significant anti-tumor activity in mice models[1] | Animal Model: | Small human tumor xenografts in mice[1] | | Dosage: | 100 mg/kg | | Administration: | Orally twice daily for 7 days | | Result: | Suppressed A375.S2 tumor growth by -50%. |
|
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
|