| Identification | Back Directory | [Name]
Pyrazine, 2,3-bis[4-(3-furanyl)phenyl]-5-(4-piperidinylmethoxy)- | [CAS]
2592638-13-4 | [Synonyms]
CBP/p300-IN-19
Pyrazine, 2,3-bis[4-(3-furanyl)phenyl]-5-(4-piperidinylmethoxy)- | [Molecular Formula]
C30H27N3O3 | [MOL File]
2592638-13-4.mol | [Molecular Weight]
477.55 |
| Hazard Information | Back Directory | [Uses]
CBP/p300-IN-19 is a potent p300/CBP HAT inhibitor with IC50s of 1.4, 2.2, >100, >100 μM for p300-HAT, CBP-HAT, PCAF, Myst3, respectively. CBP/p300-IN-19 shows antitumor activity[1]. | [IC 50]
Myst3: >100 μM (IC50); p300-HAT: 1.4 μM (IC50); CBP-HAT: 2.2 μM (IC50); PCAF: >100 μM (IC50) | [References]
[1] Nie S, et al. Structure-activity relationship and antitumor activity of 1,4-pyrazine-containing inhibitors of histone acetyltransferases P300/CBP. Eur J Med Chem. 2022 Jul 5;237:114407. DOI:10.1016/j.ejmech.2022.114407 |
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