| Chemical Properties | Back Directory | [Boiling point ]
1089.222±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.372±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
Acetonitrile: Slightly soluble: 0.1-1 mg/ml
DMSO: Sparingly soluble: 1-10 mg/ml
Water: Slightly soluble: 0.1-1 mg/ml | [form ]
Solid | [pka]
10.720±0.70(predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
JNJ-1013 is a potent and selective IRAK1 PROTAC degrader with an IC50s of 72, 443, 1071 nM for IRAK1, IRAK4, VHL FP respectively. JNJ-1013 induces apoptosis and increases the expression of cleavaged PARP. JNJ-1013 decreases the expression IRAK1, p-IKBα, pSTAT3(Tyr705) (Pink: ligand for target protein (HY-138834); black: linker (HY-Y1760); Blue: E3 ligase ligand (HY-112078))[1]. | [IC 50]
IRAK1: 72 nM (IC50); IRAK4: 443 nM (IC50); VHL FP: 1071 nM (IC50) | [References]
[1] Fu L, et al. Discovery of Highly Potent and Selective IRAK1 Degraders to Probe Scaffolding Functions of IRAK1 in ABC DLBCL. J Med Chem. 2021 Aug 12;64(15):10878-10889. DOI:10.1021/acs.jmedchem.1c00103 |
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| Company Name: |
NewCan Biotech Limited
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| Tel: |
+86-0571-86912261 +86-15658003402 |
| Website: |
https://www.newcanbio.com/ |
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