259860-08-7

1034894-73-9

259860-08-7

General procedure for the synthesis of 5-fluoro-6-bromoindole from the compound (CAS:1034894-73-9): enamine (1.89 g, 4.38 mmol) was dissolved in ethanol (35.0 mL). To this solution, iron powder (4.42 g, 79.0 mmol) and acetic acid (35.0 mL) were added, and the reaction mixture was stirred at 90 °C overnight. After completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated. The residue was purified by column chromatography (eluent: ethyl acetate/hexane, 1:9, v/v) to afford 6-bromo-5-fluoro-1H-indole as a yellow solid (0.83 g, 89% yield).1H NMR (CDCl3, 400 MHz) δ: 6.52 (m, 1H), 7.27 (m, 1H), 7.38 (d, J = 9.3 Hz, 1H) 7.57 (d, J = 5.7 Hz, 1H), 8.18 (br.s, 1H).