| Identification | Back Directory | [Name]
CUCURBIT(8)URIL | [CAS]
259886-51-6 | [Synonyms]
Cucurbit[8]uril
Curcubit[8]uril
Cucurbit[8]uril hydrate
Cucurbit[8]uril (CB[8]) hydrate
CUCURBIT(8)URIL ISO 9001：2015 REACH
Cucurbit[8]uril (CB[8]) hydrate, 99+%
Cucurbit[8]uril hydrate contains acid of crystalization
2,20:3,19-Dimethano-2,3,4a,5a,6a,7a,8a,9a,10a,11a,12a,13a,14a,15a,16a,17a,19,20,21a,22a,23a,24a,25a,26a,27a,28a,29a,30a,31a,32a,33a,34a-dotriacontaazabispentaleno[1''''',6''''':5'''',6'''',7'''']cycloocta[1'''',2'''',3'''':3''',4''']pentaleno[1''',6''':5'
2,20:3,19-Dimethano-2,3,4a,5a,6a,7a,8a,9a,10a,11a,12a,13a,14a,15a,16a,17a,19,20,21a,22a,23a,24a,25a,26a,27a,28a,29a,30a,31a,32a,33a,34a-dotriacontaazabispentaleno[1''''',6''''':5'''',6'''',7'''']cycloocta[1'''',2'''',3'''':3''',4''']pentaleno[1''',6''':5'',6'',7'']cycloocta[1'',2'',3'':3',4']pentale... | [Molecular Formula]
C48H48N32O16 | [MDL Number]
MFCD03456501 | [MOL File]
259886-51-6.mol | [Molecular Weight]
1329.1 |
| Chemical Properties | Back Directory | [density ]
2.71 | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
solid | [color ]
white | [Optical Rotation]
[α]20/D -61°, c =1% in H2O |
| Hazard Information | Back Directory | [Uses]
Cucurbit[8]uril hydrate can be used as ananocontainer in a polyelectrolyte multilayer film. | [Definition]
ChEBI: Cucurbit[8]uril is a cucurbituril. | [Synthesis]
General procedure for the synthesis of cucurbit[n]uril from glyburide and diethoxymethane: Unsubstituted glyburide (19.94 g) and pure methanesulfonic acid (82 mL) were added to a reaction flask and heated to 80 °C. Subsequently, diethoxymethane (35.21 mL) was added slowly and the reaction mixture was warmed up to 100 °C (internal temperature) and kept for 18 hours. Upon completion of the reaction, the mixture was cooled and poured into acetone (410 mL) and a brown powder was precipitated. The product composition was analyzed by 1H NMR to give cucurbit[5]uril (8%), cucurbit[6]uril (42%), cucurbit[7]uril (43%), cucurbit[8]uril (7%), cucurbit[9]uril (0%), cucurbit[10]uril (0%) and cucurbit[13]uril (0%). In addition, the residual formaldehyde content was 34 ppm by HPLC. | [in vivo]
Cucurbit[8]uril shows a very low toxicity of the in vivo intravenous injection, as well as oral administration studies on mice[2]. | [References]
[1] Patent: WO2018/115822, 2018, A1. Location in patent: Page/Page column 16 |
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