| Identification | Back Directory | [Name]
ARCHANGELICIN | [CAS]
2607-56-9 | [Synonyms]
(Z)-2-Methyl-2-butenoic acid (8S)-8,9-dihydro-8-[1-methyl-1-[(Z)-2-methyl-1-oxo-2-butenyloxy]ethyl]-2-oxo-2H-furo[2,3-h]-1-benzopyran-9α-yl ester
2-Butenoic acid, 2-methyl-, (8S,9R)-8,9-dihydro-8-[1-methyl-1-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]ethyl]-2-oxo-2H-furo[2,3-h]-1-benzopyran-9-yl ester, (2Z)- | [Molecular Formula]
C24H26O7 | [MOL File]
2607-56-9.mol | [Molecular Weight]
426.46 |
| Hazard Information | Back Directory | [Uses]
Archangelicin is an inhibitor for cAMP-phosphodiesterase (cAMP-PDE) with IC50 >400 μM. Archangelicin inhibits nuclear factor of activated T cell (NFAT) with IC50 of 9 μM. Archangelicin exhibits antitumor and anti-inflammatory[1][2][3]. | [References]
[1] Okuyama T, et al., Anti-tumor-promotion by principles obtained from Angelica keiskei. Planta Med. 1991 Jun;57(3):242-6. DOI:10.1055/s-2006-960082
[2] Thastrup O, et al., Inhibition of human platelet aggregation by dihydropyrano- and dihydrofuranocoumarins, a new class of cAMP-phosphodiesterase inhibitors. Biochem Pharmacol. 1985 Jun 15;34(12):2137-40. DOI:10.1016/0006-2952(85)90407-1
[3] Nagasawa A, et al. Angular-type Furocoumarins from the Roots of Angelica atropurpurea and their Inhibitory Activity on the NFAT Signal Transduction Pathway[J]. Natural Product Communications, 2014, 9(12): 1934578X1400901218. |
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