| Identification | Back Directory | [Name]
10H-pyrido(3,2-b)(1,4)benzothiazine | [CAS]
261-96-1 | [Synonyms]
NSC 277720
1-Azaphenothiazine
1-Azaphenothiazine>
Isothipendyl Impurity 2
Isothipendyl Impurity 1
10H-benzo[e]pyrido[3,2-b][1
PYRIDO[3,2-B][1,4]BENZOTHIAZINE
1H-Pyrido[3,2-b][1,4]benzothiazine
10H-pyrido(3,2-b)(1,4)benzothiazine
10H-Benzo[b]pyrido[2,3-e][1,4]thiazine
10H-benzo[e]pyrido[3,2-b][1,4]thiazine | [EINECS(EC#)]
205-973-7 | [Molecular Formula]
C11H8N2S | [MDL Number]
MFCD00160449 | [MOL File]
261-96-1.mol | [Molecular Weight]
200.26 |
| Chemical Properties | Back Directory | [Melting point ]
110.0 to 114.0 °C | [Boiling point ]
370°C(lit.) | [density ]
1.293 | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Dichloromethane (Slightly), DMSO (Slightly) | [form ]
Solid | [pka]
4.24±0.20(Predicted) | [color ]
Yellow to Dark Yellow | [InChI]
InChI=1S/C11H8N2S/c1-2-5-9-8(4-1)13-11-10(14-9)6-3-7-12-11/h1-7H,(H,12,13) | [InChIKey]
UKDZROJJLPDLDO-UHFFFAOYSA-N | [SMILES]
S1C2=CC=CC=C2NC2=NC=CC=C12 |
| Hazard Information | Back Directory | [Uses]
10H-Pyrido[3,2-b][1,4]benzothiazine has potential anti-cancer ability as seen through studies. | [Synthesis]
General procedure for the synthesis of azaphenothiazine from the compound (CAS: 95873-97-5): 15.0 g (119.82 mmol) of intermediate (C) was suspended with 4.36 g (119.82 mmol) of hydrochloric acid in 470 mL of ethanol and the reaction was carried out at reflux for 12 h at 70 °C under nitrogen protection. After completion of the reaction, extraction was carried out with dichloromethane and distilled water and the organic layer was filtered through silica gel. After concentrating the organic solvent, it was purified by silica gel column chromatography (eluent: ethyl acetate/petroleum ether = 7:3, v/v) to give 20.64 g of intermediate (D) in 86% yield. | [References]
[1] Patent: KR2015/12906, 2015, A. Location in patent: Paragraph 0197; 0204-0205
[2] Journal of the American Chemical Society, 1958, vol. 80, p. 1651,1653 |
| Spectrum Detail | Back Directory | [Spectrum Detail]
10H-pyrido(3,2-b)(1,4)benzothiazine(261-96-1)MS
10H-pyrido(3,2-b)(1,4)benzothiazine(261-96-1)1HNMR
10H-pyrido(3,2-b)(1,4)benzothiazine(261-96-1)13CNMR
10H-pyrido(3,2-b)(1,4)benzothiazine(261-96-1)IR1
10H-pyrido(3,2-b)(1,4)benzothiazine(261-96-1)IR2
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