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2614161-13-4

2614161-13-4 Structure

2614161-13-4 Structure
IdentificationBack Directory
[Name]

4-[[(4-Methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]methyl]-N-[2-[[[(2-thienylmethyl)amino]carbonyl]amino]ethyl]benzamide
[CAS]

2614161-13-4
[Synonyms]

MyoMed 205
4-[[(4-Methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]methyl]-N-[2-[[[(2-thienylmethyl)amino]carbonyl]amino]ethyl]benzamide
[Molecular Formula]

C26H25N3O5S
[MOL File]

2614161-13-4.mol
[Molecular Weight]

491.56
Chemical PropertiesBack Directory
[Boiling point ]

812.8±65.0 °C(Predicted)
[density ]

1.312±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
[form ]

Solid
[pka]

13.27±0.46(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

MyoMed-205 is an inhibitor targeting the activity of MuRF1. MyoMed-205 prevents early diaphragmatic systolic dysfunction and atrophy due to unilateral diaphragmatic nerve denervation 12 hours later. MyoMed-205 reduces ubiquitination and subsequent proteasomal degradation of muscle proteins by inhibiting MuRF1 activity. MyoMed-205 increases levels of a protein that phosphorylates Akt (ser473), an important signaling molecule for muscle growth and maintenance. MyoMed-205 can be used to study and treat diaphragmatic dysfunction and atrophy (DIDD) caused by early apraxia, especially in clinical situations such as diaphragmatic paralysis or mechanical ventilation[1].
[References]

[1] Ribeiro F, et al. Small-Molecule Inhibition of MuRF1 Prevents Early Disuse-Induced Diaphragmatic Dysfunction and Atrophy[J]. International Journal of Molecular Sciences, 2023, 24(4): 3637. DOI:10.3390/ijms24043637
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