| Identification | Back Directory | [Name]
METHYL 2-METHOXYISONICOTINATE 97%METHYL 2-METHOXYPYRIDINE-4-CARBOXYLATE | [CAS]
26156-51-4 | [Synonyms]
2-Methoxyisonicotinate
Methyl 2-methoxyisonicotinate 97%
Methyl 2-methoxypyridine-4-carboxylate
2-Methoxyisonicotinic acid methyl ester
2-Methoxy-4-Pyridinecarboxylic acid Methyl ester
4-Pyridinecarboxylic acid, 2-methoxy-, methyl ester
METHYL 2-METHOXYISONICOTINATE 97%METHYL 2-METHOXYPYRIDINE-4-CARBOXYLATE
2-Methoxyisonicotinic acid methyl ester
Methyl 2-methoxy-4-pyridinecarboxylate | [Molecular Formula]
C8H9NO3 | [MDL Number]
MFCD08436071 | [MOL File]
26156-51-4.mol | [Molecular Weight]
167.16 |
| Chemical Properties | Back Directory | [Melting point ]
36-38° | [Boiling point ]
120℃ (1 Torr) | [density ]
1.156±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
solid | [pka]
1.29±0.10(Predicted) | [color ]
cream |
| Hazard Information | Back Directory | [Synthesis]
Step 1 Preparation of methyl 2-methoxyisonicotinate: methyl 2-chloropyridine-4-carboxylate (5.23 g, 30.0 mmol) and sodium methanol (2.47 g, 45.0 mmol) were dissolved in 15 mL of dioxane and heated and refluxed for 1.5 hours. After the reaction was completed, it was cooled to room temperature, diluted with an appropriate amount of water and extracted with dichloromethane (3 x 20 mL). The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to give 3.76 g (75% yield) of a yellow oily product, methyl 2-methoxyisonicotinate. Elemental analysis (C8H9NO3) Calculated values: C, 57.48; H, 5.43; N, 8.38. Measured values: C, 57.07; H, 5.54; N, 8.34. | [References]
[1] Patent: US6509361, 2003, B1 |
|
|