| Identification | Back Directory | [Name]
MSX-2 | [CAS]
261717-18-4 | [Synonyms]
3-(3-Hydroxypropyl)-8-(m-methoxystyryl)-7-methyl-1-propargylxanthine
3-(3-hydroxypropyl)-8-[(E)-2-(3-methoxyphenyl)ethenyl]-7-methyl-1-prop-2-ynylpurine-2,6-dione
1H-Purine-2,6-dione, 3,7-dihydro-3-(3-hydroxypropyl)-8-[(1E)-2-(3-methoxyphenyl)ethenyl]-7-methyl-1-(2-propyn-1-yl)- | [Molecular Formula]
C21H22N4O4 | [MDL Number]
MFCD11046007 | [MOL File]
261717-18-4.mol | [Molecular Weight]
394.42 |
| Hazard Information | Back Directory | [Uses]
MSX-2 is A2A adenosine receptor antagonist, with Ki of 5 nM in human that plays an important role in Parkinson's disease[1][2]. | [References]
[1] Manuel de Lera Ruiz, et al. Adenosine A2A Receptor as a Drug Discovery Target. J Med Chem. 2014 May 8;57(9):3623-50. DOI:10.1021/jm4011669
[2] Tina Becic, et al. Growth factors FGF8 and FGF2 and their receptor FGFR1, transcriptional factors Msx-1 and MSX-2, and apoptotic factors p19 and RIP5 participate in the early human limb development. Acta Histochem. 2018 Apr;120(3):205-214. DOI:10.1016/j.acthis.2018.01.008 |
|
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
| Company Name: |
SIGMA-RBI
|
| Tel: |
800 736 3690 (Orders) |
| Website: |
www.sigma-aldrich.com |
|