| Identification | Back Directory | [Name]
2-Naphthalenol, 4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl- | [CAS]
2621928-43-4 | [Synonyms]
KRAS G12D inhibitor 1
2-Naphthalenol, 4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl- | [Molecular Formula]
C33H32F2N6O2 | [MOL File]
2621928-43-4.mol | [Molecular Weight]
582.64 |
| Chemical Properties | Back Directory | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 55 mg/mL (94.40 mM; Need ultrasonic) | [form ]
Solid | [pka]
8.11±0.40(Predicted) | [color ]
Yellow to brown |
| Hazard Information | Back Directory | [Uses]
KRAS G12D inhibitor 1 (example 243) is a KRAS G12D inhibitor, with an IC50 of 0.8 nM for KRAS G12D-mediated ERK phosphorylation[1]. KRAS G12D inhibitor 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [Biological Activity]
KRAS G12D inhibitor 1 (example 243) is a KRAS G12D inhibitor, with an IC50 of 0.8 nM for KRAS G12D-mediated ERK phosphorylation[1]. | [References]
[1]. WANG XIAOLUN (US), et al. KRAS G12D INHIBITORS. WO2021041671. |
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