| Identification | Back Directory | [Name]
Acetic acid, 2-[4-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)phenoxy]- | [CAS]
2633633-12-0 | [Synonyms]
2-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenoxy)acetic acid
Acetic acid, 2-[4-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)phenoxy]- | [Molecular Formula]
C12H12N2O5 | [MOL File]
2633633-12-0.mol | [Molecular Weight]
264.24 |
| Hazard Information | Back Directory | [Uses]
PD 4'-oxyacetic acid is a carboxylic acid-functionalized cereblon ligand that can be used for PROTAC Degrader development[1]. | [Biological Activity]
PD 4'-oxyacetic is a carboxylic acid-functionalized cereblon ligand that can be used for PROTAC? Degrader development. The compound can be used to develop PD-PROTACs that exhibit improved stability and potency compared with PROTACs synthesized using IMiD (immunomodulatory imide drug) analogs. | [IC 50]
Cereblon | [storage]
Store at -20°C | [References]
[1] Jarusiewicz JA, et al. Phenyl Dihydrouracil: An Alternative Cereblon Binder for PROTAC Design. ACS Med Chem Lett. 2023;14(2):141-145. Published 2023 Jan 4. DOI:10.1021/acsmedchemlett.2c00436 |
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