| Identification | Back Directory | [Name]
Benzothiazole, 2-[4,5-bis[4-(4-methyl-1-piperazinyl)phenyl]-1H-imidazol-2-yl]- | [CAS]
2636771-45-2 | [Synonyms]
IZTZ-1
Benzothiazole, 2-[4,5-bis[4-(4-methyl-1-piperazinyl)phenyl]-1H-imidazol-2-yl]- | [Molecular Formula]
C32H35N7S | [MOL File]
2636771-45-2.mol | [Molecular Weight]
549.73 |
| Hazard Information | Back Directory | [Uses]
IZTZ-1, an imidazole-benzothiazole conjugate, is a c-MYC G4 ligand. IZTZ-1 is able to downregulate the c-MYC expression by stabilizing c-MYC G4. IZTZ-1 induces cell cycle arrest, apoptosis, thereby inhibiting cell proliferation in B16 cells. IZTZ-1 shows antitumor activity, and can be used for melanoma research[1]. | [in vivo]
IZTZ-1 (0-20 mg/kg, IP, once every two days, for 10 days) effectively inhibits tumor growth in a melanoma mouse model[1]. | [References]
[1] Wu TY, et al. A drug-like imidazole-benzothiazole conjugate inhibits malignant melanoma by stabilizing the c-MYC G-quadruplex. Bioorg Chem. 2020 Jun;99:103866. DOI:10.1016/j.bioorg.2020.103866 |
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