| Identification | Back Directory | [Name]
1,4-Cyclohexanediamine, N4-[2-[3-[[2-methoxy-4-(trifluoromethyl)phenyl]amino]-1-propyn-1-yl]-1-(2,2,2-trifluoroethyl)-1H-indol-4-yl]-N1,N1-dimethyl-, trans- | [CAS]
2636840-37-2 | [Synonyms]
p53 Activator 5
1,4-Cyclohexanediamine, N4-[2-[3-[[2-methoxy-4-(trifluoromethyl)phenyl]amino]-1-propyn-1-yl]-1-(2,2,2-trifluoroethyl)-1H-indol-4-yl]-N1,N1-dimethyl-, trans- | [Molecular Formula]
C29H32F6N4O | [MOL File]
2636840-37-2.mol | [Molecular Weight]
566.58 |
| Chemical Properties | Back Directory | [Boiling point ]
636.1±55.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
10.61±0.70(Predicted) | [color ]
Brown to reddish brown |
| Hazard Information | Back Directory | [Uses]
p53 Activator 5 (compound 134A) is a potent p53 activator with a SC150 value of <0.05 mM. p53 Activator 5 can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA. p53 Activator 5 shows anti-tumor activity[1]. p53 Activator 5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] VU, Binh, et al. Methods and compounds for restoring mutant p53 function, WO2021061643. |
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