| Identification | Back Directory | [Name]
2-Pyridinepropanoic acid, 5-[5-[[(5-fluoro-2,3-dihydro-4-benzofuranyl)methyl]amino]-1,2,4-triazolo[4,3-c]pyrimidin-8-yl]-6-methyl- | [CAS]
2639882-68-9 | [Synonyms]
2-Pyridinepropanoic acid, 5-[5-[[(5-fluoro-2,3-dihydro-4-benzofuranyl)methyl]amino]-1,2,4-triazolo[4,3-c]pyrimidin-8-yl]-6-methyl- | [Molecular Formula]
C23H21FN6O3 | [MOL File]
2639882-68-9.mol | [Molecular Weight]
448.45 |
| Hazard Information | Back Directory | [Biological Activity]
MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 and PROTAC EED degrader-2 [1].
MAK683-CH2CH2COOH inhibits Karpas422 cells with a GI50 of 14 nM for 14 days treatment[1]. | [References]
[1]. Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9. |
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