| Identification | Back Directory | [Name]
Methanone, [4-[[3-(2-benzothiazolylamino)-2-methylphenyl]methyl]-1-piperazinyl]cyclopentyl- | [CAS]
2641758-86-1 | [Synonyms]
RORγt/DHODH-IN-2
Methanone, [4-[[3-(2-benzothiazolylamino)-2-methylphenyl]methyl]-1-piperazinyl]cyclopentyl- | [Molecular Formula]
C25H30N4OS | [MOL File]
2641758-86-1.mol | [Molecular Weight]
434.6 |
| Hazard Information | Back Directory | [Uses]
RORγt/DHODH-IN-2 (compound 1) is a potent dual RORγt/DHODH inhibitor. RORγt/DHODH-IN-2 can be used for inflammatory bowel disease (IBD) research[1]. | [References]
[1] Ji-An Chen, et al. Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease. J Med Chem. 2022 Jan 13;65(1):592-615. DOI:10.1021/acs.jmedchem.1c01746 |
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