| Identification | Back Directory | [Name]
Benzenesulfonamide, N-[3-[5-(2-amino-4-pyrimidinyl)-2-(3-morpholinyl)-4-thiazolyl]-5-chloro-2-fluorophenyl]-2,5-difluoro- | [CAS]
2648698-30-8 | [Synonyms]
B-Raf IN 5
Benzenesulfonamide, N-[3-[5-(2-amino-4-pyrimidinyl)-2-(3-morpholinyl)-4-thiazolyl]-5-chloro-2-fluorophenyl]-2,5-difluoro- | [Molecular Formula]
C23H18ClF3N6O3S2 | [MOL File]
2648698-30-8.mol | [Molecular Weight]
583.01 |
| Hazard Information | Back Directory | [Uses]
B-Raf IN 5 (compound 3b) is a potent inhibitor of protein kinase B-Raf with an IC50 of 2.0 nM. B-Raf IN 5 is devoid of binding to the secondary target PXR and resists rapid metabolism. B-Raf IN 6 has the potential for the research of cancer disease[1]. | [References]
[1] Schneider M, et al. Structure-Based and Knowledge-Informed Design of B-Raf Inhibitors Devoid of Deleterious PXR Binding. J Med Chem. 2022;65(2):1552-1566. DOI:10.1021/acs.jmedchem.1c01354 |
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