| Identification | Back Directory | [Name]
1-Methyl-4-[4-methyl-4-(5-methyl-2-benzoxazolyl)-1-piperidyl]-2-oxo-7-[(3-tetrahydrofuryl)oxy]-1,2-dihydroquinoline-3,6-dicarbonitrile | [CAS]
2648723-43-5 | [Synonyms]
DGKα-IN-4
1-Methyl-4-[4-methyl-4-(5-methyl-2-benzoxazolyl)-1-piperidyl]-2-oxo-7-[(3-tetrahydrofuryl)oxy]-1,2-dihydroquinoline-3,6-dicarbonitrile |
| Hazard Information | Back Directory | [Uses]
DGKα-IN-4 (example 432) is a DGKα inhibitor with the IC50 of 0.1 nM, extracted from patent WO2021105117. DGKα-IN-2 significantly enhances the anti-tumor effect of anti-PD-1 by increasing the proliferation and function of T cells. DGKα-IN-3 has the potential for cancer and immunology study. | [References]
[1] Schmees, Norbert, et al. Preparation of substituted aminoquinolones as DGKα inhibitors for immune activation. WO2021105117. |
|
|