| Identification | Back Directory | [Name]
N4-Butyl-6-[[4-(2-oxa-6-azaspiro[3.3]hept-6-ylmethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine | [CAS]
2649170-16-9 | [Synonyms]
TLR7/8 agonist 8
N4-Butyl-6-[[4-(2-oxa-6-azaspiro[3.3]hept-6-ylmethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine | [Molecular Formula]
C24H30N6O | [MOL File]
2649170-16-9.mol | [Molecular Weight]
418.54 |
| Chemical Properties | Back Directory | [Boiling point ]
639.0±65.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
7.96±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TLR7/8 agonist 8 (compound 24m) is a potent toll-like receptor 7/8 (TLR7/8) dual agonist, with EC50s of 27 and 12 nM for hTLR7 and hTLR8, respectively. TLR7/8 agonist 8 can improve the antitumor activity of PD-1/PD-L1 blockade[1]. | [IC 50]
TLR7: 27 nM (EC50); TLR8: 12 nM (EC50) | [References]
[1] Wang Z, et, al. Structure-Based Design of Highly Potent Toll-like Receptor 7/8 Dual Agonists for Cancer Immunotherapy. J Med Chem. 2021 Jun 10;64(11):7507-7532. DOI:10.1021/acs.jmedchem.1c00179 |
|
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
|