| Identification | Back Directory | [Name]
Boronic acid, B-[3-[[[[5-chloro-3-[(3,5-dimethylphenyl)sulfonyl]-1H-indol-2-yl]carbonyl]amino]methyl]phenyl]- | [CAS]
2649837-82-9 | [Synonyms]
HIV-1 inhibitor-19
Boronic acid, B-[3-[[[[5-chloro-3-[(3,5-dimethylphenyl)sulfonyl]-1H-indol-2-yl]carbonyl]amino]methyl]phenyl]- | [Molecular Formula]
C24H22BClN2O5S | [MOL File]
2649837-82-9.mol | [Molecular Weight]
496.77 |
| Hazard Information | Back Directory | [Uses]
HIV-1 inhibitor-19 is a potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI). HIV-1 inhibitor-19 maintains its inhibitory activity against L100I, K103N and V106A/ F227L mutant strains with EC50s of 7.3?nM, 9.2?nM and?21.0?nM, respectively[1]. | [References]
[1] Shujing Xu, et al. Indolylarylsulfones bearing phenylboronic acid and phenylboronate ester functionalities as potent HIV?1 non-nucleoside reverse transcriptase inhibitors. Bioorg Med Chem. 2022 Jan 1;53:116531. DOI:10.1016/j.bmc.2021.116531 |
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