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2650944-83-3

2650944-83-3 Structure

2650944-83-3 Structure
IdentificationBack Directory
[Name]

Ethanone, 2-[4-(5-fluoro-2-pyridinyl)-1-piperazinyl]-1-(2-methylimidazo[1,2-a]pyridin-3-yl)-
[CAS]

2650944-83-3
[Synonyms]

FATP1-IN-2
Ethanone, 2-[4-(5-fluoro-2-pyridinyl)-1-piperazinyl]-1-(2-methylimidazo[1,2-a]pyridin-3-yl)-
[Molecular Formula]

C19H20FN5O
[MOL File]

2650944-83-3.mol
[Molecular Weight]

353.39
Chemical PropertiesBack Directory
[density ]

1.33±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[form ]

Solid
[pka]

6.00±0.29(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

FATP1-IN-2 (compound 12a), an arylpiperazine derivative, is an orally active fatty acid transport protein 1 (FATP1) inhibitor (human IC50=0.43 μM, mouse IC50=0.39 μM)[1].
[Biological Activity]

FATP1-IN-2, as an arylpiperazine derivative, is an orally active fatty acid transport protein 1 (FATP1) inhibitor (human IC50=0.43 μM, mouse IC50=0.39 μM)[1]. FATP1-IN-2 (10 mg/kg; p.o.) shows a Cmax value above the mouse IC50 value[1].FATP1-IN-2 (3, 10, 30 mg/kg; p.o.; 4 weeks) shows TG content of each tissue does not change at any dose[1].
[in vivo]

FATP1-IN-2 (10 mg/kg; p.o.) shows a Cmax value above the mouse IC50 value[1].
FATP1-IN-2 (3, 10, 30 mg/kg; p.o.; 4 weeks) shows TG content of each tissue does not change at any dose[1].

Animal Model:Mice[1]
Dosage:10 mg/kg
Administration:P.o.
Result:Showed a Cmax value above the mouse IC50 value.
[References]

[1]. Matsufuji T, et al. Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties. Bioorg Med Chem Lett. 2013;23(9):2560-2565.
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