| Identification | Back Directory | [Name]
1H-Benzimidazol-6-amine,1-methyl-(9CI) | [CAS]
26530-93-8 | [Synonyms]
3-methyl-5-benzimidazolamine
3-methylbenzimidazol-5-amine
(3-methylbenzimidazol-5-yl)amine
1-methyl-1H-benzimidazol-6-amine
1H-benzimidazol-6-amine, 1-methyl-
1-Methyl-1H-benzo[d]imidazol-6-amine
1H-Benzimidazol-6-amine,1-methyl-(9CI)
1-methyl-1H-benzimidazol-6-amine(SALTDATA: FREE) | [Molecular Formula]
C8H9N3 | [MDL Number]
MFCD09764050 | [MOL File]
26530-93-8.mol | [Molecular Weight]
147.18 |
| Chemical Properties | Back Directory | [Melting point ]
160 °C | [Boiling point ]
180-185 °C(Press: 4 Torr) | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [pka]
6.16±0.10(Predicted) | [Appearance]
Off-white to pink Solid |
| Hazard Information | Back Directory | [Synthesis]
General method: Step B: 1-methyl-6-nitro-1H-benzo[d]imidazole or 1-methyl-5-nitro-1H-benzo[d]imidazole is dissolved in methanol (or a solvent mixture of methanol and tetrahydrofuran), followed by the addition of 10% palladium/carbon catalyst. The reaction mixture was stirred at room temperature in a hydrogen atmosphere until thin layer chromatography (TLC) monitoring showed complete consumption of the feedstock. Upon completion of the reaction, the crude reaction solution was filtered through a diatomaceous earth pad and the filter cake was washed well with methanol. The filtrate was concentrated under reduced pressure and the resulting products, 1-methylbenzimidazol-5-amine or 1-methyl-1H-benzimidazol-6-amine, could be used directly in the subsequent reaction or further purified by silica gel column chromatography to obtain higher purity products. | [References]
[1] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 13, p. 3821 - 3830 |
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