| Identification | Back Directory | [Name]
1H-Benzimidazole-1-acetamide, 2-(4-amino-1,2,5-oxadiazol-3-yl)-N-(3-bromo-5-cyanophenyl)- | [CAS]
2653349-78-9 | [Synonyms]
BChE-IN-8
1H-Benzimidazole-1-acetamide, 2-(4-amino-1,2,5-oxadiazol-3-yl)-N-(3-bromo-5-cyanophenyl)- | [Molecular Formula]
C18H12BrN7O2 | [MOL File]
2653349-78-9.mol | [Molecular Weight]
438.24 |
| Hazard Information | Back Directory | [Uses]
BChE-IN-8 (compound 20) is an orally active, potent and BBB-penetrated BChE (butyrylcholinesterase) inhibitor, with IC50 values of 0.15 nM (eqBChE, equine serum BChE) and 45.2 nM (hBChE), respectively. High stability of BChE-IN-8 contributes to significantly improved blood concentration and tissue exposure. BChE-IN-8 can exert neuro-protecting and cognition improving properties through multiple modulations, including cholinergic system, Aβ aggregation, neuropeptide levels. BChE-IN-8 can be used for Alzheimer's disease (AD) research[1]. | [References]
[1] Li Q, Xiong B, Wang Y, Lyu W, Xing S, Chen Y, Liao Q, He S, Feng F, Liu W, Chen Y, Sun H. A highly effective and stable butyrylcholinesterase inhibitor with multi-faceted neuroprotection and cognition improvement. Eur J Med Chem. 2022 Jun 7;239:114510. DOI:10.1016/j.ejmech.2022.114510 |
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