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BIIB 513 is an inhibitor of NHE 1 that protects against myocardial ischemia. BIIB 513 inhibits acid load recovery with an IC50 of 27 nmol/L in cells expressing wild-type NHE 1 under acute acid load[1]. | [References]
[1] Gumina, et al. "Inhibition of the Na+/H+ exchanger confers greater cardioprotection against 90 minutes of myocardial ischemia than ischemic preconditioning in dogs." Circulation 100.25 (1999): 2519-2526. DOI:10.1161/01.cir.100.25.2519 |
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