IRAK4-IN-14 (i.v. or p.o.) shows good PK parameters with oral bioavailability of 66% for mouse[1].
Pharmacokinetic Parameters of IRAK4-IN-14 in Male Han Wistar rats, male CD1 mice, male Cynomolgus monkeys[1].
| parameter | | Value |
| A2B Papp | | 31 |
| Efflux ratio | | 1.4 |
| Solubility (μM) | | 800 |
| Rat/mouse/monkey/human %free | | 21/16/33/21 |
| Rat LM/H CLint | | 16/5.6 |
| Mouse LM/H CLint | | 13/11 |
| Minipig LM/H CLint | | 18/8.2 |
| Dog LM/H CLint | | 21/4.5 |
| Monkey LM/H CLint | | 35/4.7 |
| Rat | CL | 15 |
| Vdss | 4.3 |
| t1/2 | 5.2 |
| F% | 55% |
| Mouse | CL | 17 |
| Vdss | 4.1 |
| t1/2 | 4.2 |
| F% | 66% |
| Monkey | CL | 68 |
| Vdss | 8.6 |
| t1/2 | 1.4 |
Male Han Wistar rats; 1 mg/kg i.v.; 2 mg/kg p.o.; Male CD1 mice; 0.5 mg/kg i.v.; 1 mg/kg p.o.; Male Cynomolgus monkeys; 1 mg/kg i.v.
[1].