| Identification | Back Directory | [Name]
9H-Pyrido[3,4-b]indole-7-carboxylic acid, 1-[(cyclopropylcarbonyl)amino]-, methyl ester | [CAS]
2668297-70-7 | [Synonyms]
ZDWX-25
9H-Pyrido[3,4-b]indole-7-carboxylic acid, 1-[(cyclopropylcarbonyl)amino]-, methyl ester | [Molecular Formula]
C17H15N3O3 | [MOL File]
2668297-70-7.mol | [Molecular Weight]
309.32 |
| Hazard Information | Back Directory | [Uses]
ZDWX-25 is a highly potent GSK-3β and DYRK1A dual inhibitor with an IC50 value of 71 nM for GSK-3β. ZDWX-25 possesses significant cytotoxic activities against SH-SY5Y and HL-7702 cells. ZDWX-25 can be used for researching alzheimer's disease[1]. | [IC 50]
GSK-3β: 71 nM (IC50) | [References]
[1] Liu W, et al. Discovery of novel β-carboline derivatives as selective AChE inhibitors with GSK-3β inhibitory property for the treatment of Alzheimer's disease. Eur J Med Chem. 2022;229:114095. DOI:10.1016/j.ejmech.2021.114095 |
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