| Identification | Back Directory | [Name]
2,5-dioxopyrrolidm-1 -yl 1 -(2,5-dioxo2,5-dihydro-1 H-pyrrol-1 -yl)-3,6.9,12.15t18,21,24.27,30,33,36-dodecaoxanonatnacontan-39-oate | [CAS]
2669737-09-9 | [Synonyms]
2,5-dioxopyrrolidm-1 -yl 1 -(2,5-dioxo2,5-dihydro-1 H-pyrrol-1 -yl)-3,6.9,12.15t18,21,24.27,30,33,36-dodecaoxanonatnacontan-39-oate | [Molecular Formula]
C35H58N2O18 | [MOL File]
2669737-09-9.mol | [Molecular Weight]
794.85 |
| Chemical Properties | Back Directory | [Boiling point ]
789.4±70.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Liquid | [pka]
-2.34±0.20(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Mal-PEG12-NHS ester is a PEG linker containing a maleimide group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | [Uses]
Mal-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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