| Identification | Back Directory | [Name]
Pyrazino[1,2-a]benzimidazol-1(2H)-one, 3,4-dihydro-2-[4-[4-(trifluoromethoxy)phenoxy]butyl]- | [CAS]
2671063-84-4 | [Synonyms]
mGluR2 modulator 1
Pyrazino[1,2-a]benzimidazol-1(2H)-one, 3,4-dihydro-2-[4-[4-(trifluoromethoxy)phenoxy]butyl]- | [Molecular Formula]
C21H20F3N3O3 | [MOL File]
2671063-84-4.mol | [Molecular Weight]
419.4 |
| Chemical Properties | Back Directory | [Boiling point ]
541.9±60.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
4.15±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
mGluR2 modulator 1 (compound 95) is a potent and BBB-penetrated mGluR2 (metabotropic glutamate receptor-2) positive allosteric modulator, with an EC50 of 0.03 μM. mGluR2 modulator 1 can be used for psychosis research[1]. | [IC 50]
mGluR2: 0.03 ± 0.0 μM (EC50) | [References]
[1] Szabó G, et al. Discovery of dihydropyrazino-benzimidazole derivatives as metabotropic glutamate receptor-2 (mGluR2) positive allosteric modulators (PAMs). Eur J Med Chem. 2020 Jan 15;186:111881. DOI:10.1016/j.ejmech.2019.111881 |
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