| Identification | Back Directory | [Name]
4-(N,N-DIETHYLAMINOCARBONYL)METHYL-4,4',4"-
TRIMETHYLCURCUMIN-D3 | [CAS]
2673270-28-3 | [Synonyms]
4-(N,N-DIETHYLAMINOCARBONYL)METHYL-4,4',4"-
TRIMETHYLCURCUMIN-D3 |
| Hazard Information | Back Directory | [Uses]
TML-6-d3 is the deuterium labeled TML-6. TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti- | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Ih-Jen Su, et al. A Curcumin Analog Exhibits Multiple Biologic Effects on the Pathogenesis of Alzheimer's Disease and Improves Behavior, Inflammation, and β-Amyloid Accumulation in a Mouse Model. Int J Mol Sci. 2020 Jul 30;21(15):5459. DOI:10.3390/ijms21155459 |
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