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2673270-28-3

2673270-28-3 Structure

2673270-28-3 Structure
IdentificationBack Directory
[Name]

4-(N,N-DIETHYLAMINOCARBONYL)METHYL-4,4',4"- TRIMETHYLCURCUMIN-D3
[CAS]

2673270-28-3
[Synonyms]

4-(N,N-DIETHYLAMINOCARBONYL)METHYL-4,4',4"- TRIMETHYLCURCUMIN-D3
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[Uses]

TML-6-d3 is the deuterium labeled TML-6. TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-
[References]

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Ih-Jen Su, et al. A Curcumin Analog Exhibits Multiple Biologic Effects on the Pathogenesis of Alzheimer's Disease and Improves Behavior, Inflammation, and β-Amyloid Accumulation in a Mouse Model. Int J Mol Sci. 2020 Jul 30;21(15):5459. DOI:10.3390/ijms21155459
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Company Name: Nanjing Shizhou Biology Technology Co.,Ltd  
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Website: www.synzest.com
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