| Identification | Back Directory | [Name]
Benzoic acid, 2-[1-[3-(1-naphthalenyloxy)propyl]-1H-indol-4-yl]- | [CAS]
2673361-08-3 | [Synonyms]
Bcl-2/Mcl-1-IN-1
Benzoic acid, 2-[1-[3-(1-naphthalenyloxy)propyl]-1H-indol-4-yl]- | [Molecular Formula]
C28H23NO3 | [MOL File]
2673361-08-3.mol | [Molecular Weight]
421.49 |
| Hazard Information | Back Directory | [Uses]
Bcl-2/Mcl-1-IN-1 (compound 3) is a Bcl-2/Mcl-1 inhibitor, with Kis of 1.19 μM and 4.53 μM for Mcl-1 and Bcl-2, respectively. Bcl-2/Mcl-1-IN-1 can be used for the research of cancer[1]. | [IC 50]
Mcl-1: 1.19 μM (Ki); Bcl-2: 4.53 μM (Ki) | [References]
[1] Niu Q, et, al. Design, synthesis and biological evaluation of dual Bcl-2/Mcl-1 inhibitors bearing 2-(1H-indol-4-yl)benzoic acid scaffold. Bioorg Med Chem Lett. 2021 Sep 1;47:128215. DOI:10.1016/j.bmcl.2021.128215 |
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