| Chemical Properties | Back Directory | [Boiling point ]
573.878±50.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.226±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [color ]
Light yellow to green yellow |
| Hazard Information | Back Directory | [Uses]
NiCur is a potent and selective CBP histone acetyltransferase (HAT) inhibitor with an IC50 value of 0.35 μΜ. NiCur, which blocks CBP HAT activity and downregulates p53 activation upon genotoxic stress. NiCur can be used for performing mechanistic studies without affecting the expression of target proteins[1]. | [IC 50]
CBP-HAT: 0.35 μM (IC50) | [References]
[1] Vincek AS, et al. Inhibitor of CBP Histone Acetyltransferase Downregulates p53 Activation and Facilitates Methylation at Lysine 27 on Histone H3. Molecules. 2018;23(8):1930. Published 2018 Aug 2. DOI:10.3390/molecules23081930 |
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