| Identification | Back Directory | [Name]
3-Isoxazolecarboxamide, N-[(1R)-2,3-dihydro-1H-inden-1-yl]-5-[4-[(dimethylamino)carbonyl]-3-hydroxyphenyl]- | [CAS]
2675452-91-0 | [Synonyms]
PFI-6
3-Isoxazolecarboxamide, N-[(1R)-2,3-dihydro-1H-inden-1-yl]-5-[4-[(dimethylamino)carbonyl]-3-hydroxyphenyl]- | [Molecular Formula]
C22H21N3O4 | [MOL File]
2675452-91-0.mol | [Molecular Weight]
391.42 |
| Chemical Properties | Back Directory | [Boiling point ]
694.9±55.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
7.52±0.35(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
PFI-6 is a non-cytotoxic and selective MLLT1/3 probe targeting the YEATS domain of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3). PFI-6 shows IC50 values of 140 nM and 160 nM for MLLT1 and MLLT3, respectively. PFI-6 can serve as a molecular tool to explore the role of MLLT1/3 in various diseases and related genome validation studies[1]. | [Biological Activity]
PFI-6 is a cell penetrantpotent and selective inhibitor of MLLT1/3. PFI-6 binds into the YEATS domain of MLLT1/3. | [References]
[1] Raux B, et al. Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3. Bioorg Med Chem Lett. 2023 Nov 7:129546. DOI:10.1016/j.bmcl.2023.129546 |
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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