| Identification | Back Directory | [Name]
4-Quinazolinamine, N-(4-chloro-3-ethynylphenyl)-6,7-dimethoxy- | [CAS]
2676156-05-9 | [Synonyms]
UNC-CA359
4-Quinazolinamine, N-(4-chloro-3-ethynylphenyl)-6,7-dimethoxy- | [Molecular Formula]
C18H14ClN3O2 | [MOL File]
2676156-05-9.mol | [Molecular Weight]
339.78 |
| Hazard Information | Back Directory | [Uses]
UNC-CA359 is a potent epidermal growth factor receptor (EGFR) inhibitor, with an IC50 value of 18 nM. UNC-CA359 exhibits strong anti-tumor activity, can be used to Chordoma research[1]. UNC-CA359 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] Bieberich AA, et al. Optimization of the 4-anilinoquin(az)oline scaffold as epidermal growth factor receptor (EGFR) inhibitors for chordoma utilizing a toxicology profiling assay platform. Sci Rep. 2022 Jul 27. 12(1):12820. DOI:10.1038/s41598-022-15552-5
[2] Asquith CRM, et al. Design and Analysis of the 4-Anilinoquin(az)oline Kinase Inhibition Profiles of GAK/SLK/STK10 Using Quantitative Structure-Activity Relationships. ChemMedChem. 2020 Jan 7. 15(1):26-49. DOI:10.1002/cmdc.201900521 |
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