| Identification | Back Directory | [Name]
Acetamide, 2-[(5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl)oxy]-N-[(3-methylphenyl)methyl]- | [CAS]
2680554-46-3 | [Synonyms]
PXYD3
Acetamide, 2-[(5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl)oxy]-N-[(3-methylphenyl)methyl]- | [Molecular Formula]
C25H21NO5 | [MOL File]
2680554-46-3.mol | [Molecular Weight]
415.44 |
| Hazard Information | Back Directory | [Uses]
PXYD3 is a ribosomal protein S1 (RpsA) antagonist with Kds of 5.66 and 6.91 μM for RpsA-CTD and RpsA-CTD Δ438A, respectively. RpsA plays an important role in the trans-translation process of Mycobacterium Tuberculosis (Mtb)[1]. | [References]
[1] Yazhuang Dai, et al. Discovery and evaluation of new compounds targeting ribosomal protein S1 in antibiotic-resistant Mycobacterium Tuberculosis. Eur J Med Chem. 2020 Jun 15;196:112317. DOI:10.1016/j.ejmech.2020.112317 |
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